Seroprevalence of Bactericidal and Anti-Outer Membrane Vesicle Antibodies to Neisseria meningitidis Group B in England
نویسندگان
چکیده
منابع مشابه
Additive and synergistic bactericidal activity of antibodies directed against minor outer membrane proteins of Neisseria meningitidis.
Neisseria meningitidis serogroup B is a major cause of bacterial meningitis in younger populations. The available vaccines are based on outer membrane vesicles obtained from wild-type strains. In children less than 2 years old they confer protection only against strains expressing homologous PorA, a major, variable outer membrane protein (OMP). We genetically modified a strain in order to elimi...
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The immunogenicity to several meningococcal polysaccharide-protein conjugates was evaluated in mice. The purified polysaccharide from N. meningitidis serogroup C (PsC) was linked to different quantities of outer membrane vesicle from N. meningitidis serogroup B (OMV) (3, 6 and 9 mg) as carrier protein, via carbodiimide-mediated reaction. The conjugates were inoculated in Balb/c mice in three do...
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Neisseria meningitidis is a major causative agent of bacterial septicemia and meningitis in humans. Currently, there are no vaccines to prevent disease caused by strains of N.meningitidis serogroup B. The Class 1 Outer Membrane Protein (OMP) has been named porA which is a cation selective transmembrane protein of 45 KDa that forms trimeric pore in the meningococcal outer membrane. PorA from ser...
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conclusions the results showed that the extracted omvs were conformationally stable, and there were no pyrogenic determinants in omv. also the results showed that the omv elicited high level of specific antibodies against n. meningitidis serogroup a. these results indicate that the omv obtained here, can be used as a meningococcal vaccine after further investigation. materials and methods omvs ...
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Meningococcal groups B and C have been subdivided into a series of serotypes based upon the antigenic specificity of protein serotype antigens (STA). The purpose of these studies was to obtain the STA by gentle methods and determine its anatomic location in the meningococcal cell. The STA was extracted from group B meningococcal strains by either 0.2 M LiCl or 0.2 M CaCl(2) and isolated from th...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2007
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00102-07